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KMID : 0352119920080030412
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Journal of Kyung Hee University
1992 Volume.8 No. 3 p.412 ~ p.418
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Responses of Electrical Stimulation at Shuigou Point (GV 26) on Blood Pressure, Pulse, and Regional Cerebral Blood Flow in Rats
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Abstract
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This experiment was to investigate the effects of electrical stimulation at Shuigou point of meridian vessels on blood pressure, pulse, and regional cerebral blood flow in rats.
27 female Sprague-Dawley rats weighing 250-300 g were used. Each animal was anesthetized with 4% halothane in 70:30 mixture nitrous oxide and oxygen in anesthetizing box at the induction and 0.9% hlothane brown by nasal mask during operation.
Self-respiration was well maintained. Right arterial femoral catheter was connected to a Statham transducer to continously monitor systmeic blood pressure and pulse on a chart recorder. Animal was mounted in a stereotaxic apparatus, and then
halothane
inhalation was discontinued. The total inhalation time of halothane was less than 20 minutes. But when checking the blood pressure and heart rates, each animal received 20 mg/kg pentobarbital sodium intraperitonealy. Shuigou point was
electrically
stimulated with cathodal square-wave pulses delivered through bipolar electrode fabricated from stainless stell wire. Stimulus parameter were 0.7 mA intensity, 5 ms duration, 3 Hz (n=10) and 100 Hz (n=17) frequency for 15 min with measuring CBF
and
for
5 min with checking blood pressure and heart rate, respectively, CBF was measured using the hydrogen clearance technique.
@ES The results were as follows:
@EN 1) A significant increases of mean arterial blood pressure was observed following electrical stimulation in 100 Hz stimulated group (p<0.05). there was a increasing tendancy but not significant difference after stimulationin in 3 Hz
stimulated
group. There was not a significant difference between 3 Hz stimulated groups following stimulation.
2) There was not a significant difference following stimulation and between two groups on heart beats.
3) No changes in cerebral blood flow was noted after electrical stimulation of Shuigou point under unanesthetized states.
Through the literature studies on this subject and the results of this experiment, although Shuigou point is used commonly in the acute stage of stroke, it is suggested that this point is carefully applied under the increased blood pressure. Thus
indications of Shuigou point in acute stage of stroke might be re-estabilished and further studies will be needed.
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